30. Jobin-Des Lauriers, A.; Legault, C. Y.* "Metathetical Redox Reaction of (Diacetoxyiodo)arenes and Iodoarenes" Molecules 2015, 20, 22635-22644. (Feature article (Invited) to special issue on Hypervalent Iodine Chemistry) (link)

29. Basdevant, B.; Legault, C. Y.* "Enantioselective Iodine(III)-Mediated Synthesis of α-Tosyloxy Ketones: Breaking the Selectivity Barrier" Org. Lett. 2015, 17, 4918-4921. (link)

28. Beaulieu, S.; Legault, C. Y.* "Mechanistic Insights on the Iodine(III)-Mediated α-Oxidation of Ketones" Chem. Eur. J. 2015, 21, 11206-11211. (link)

27. Basdevant, B.; Legault, C. Y.* "Study of the Reactivity of [Hydroxy(tosyloxy)iodo]benzene Toward Enol Esters to Access α‐Tosyloxy Ketones" J. Org. Chem. 2015, 80, 6897–6902. (link)

26. Langdon, S. M.; Legault, C. Y.*; Gravel, M.* "Origin of Chemoselectivity in N-Heterocyclic Carbene-Catalyzed Cross-Benzoin Reactions: DFT and Experimental Insights" J. Org. Chem. 2015, 80, 3597-3610. (link)

25. Petiot, P.; Dansereau, J.; Hébert, M.; Khene, I.; Ahmad, T.; Samaali, S.; Leroy, M.; Pinsonneault, F.; Legault, C. Y.*, Gagnon, A.* “Copper-Catalyzed O-Arylation of N-Protected 1,2-Aminoalcohols Using Functionalized Trivalent Organobismuth Reagents” Organic & Biomolecular Chemistry 2015, 13, 1322-1327. (link)

24. Champagne, P. A.; Drouin, M.; Legault, C. Y.; Audubert, C.; Paquin, J.-F.* “Revised Mechanistic Explanation for the Alcohol-Promoted Amination of Benzylic Fluorides under Highly Concentrated Conditions: Computational and Experimental Evidence on a Model Substrate” Journal of Fluorine Chemistry 2015, 117, 113-119. (link)


23. Schneider, Y.; Prévost, J.; Gobin, M.; Legault, C. Y.* “Diazirines as Potent Electrophilic Nitrogen Sources: Application to the Synthesis of Pyrazoles” Org. Lett. 2014, 16, 596–599. (link)(Highlighted in Synfacts 2014, 10, 418)

22. Ba, S.; Haroune, L.; Cruz-Morato, C.; Jacquet, C.; Touahar, I. E.; Bellenger, J.-P.; Legault, C. Y.; Jones, P. J.; Cabana, H.* “Enzymatic transformation of acetaminophen from municipal and hospital wastewaters using combined cross-linked laccase and tyrosinase aggregates” Science of the Total Environment 2014, 487, 748-755. (link)

21. Haroune, L.; Salaun, M.; Ménard, A.; Legault, C. Y.; Bellenger, J.-P.* “Photocatalytic degradation of carbamazepine and three derivatives using TiO2 and ZnO: effect of pH, ionic strength and natural organic matter” Science of the Total Environment 2014, 475, 16-22. (link).


20. Thérien, M.-E.; Guilbault, A.-A.; Legault, C. Y.* “New Chiral Iodooxazolines Catalysts for the I(III)-mediated α-Tosyloxylation of Ketones : Refining the Stereoinduction Model” Tetrahedron: Asymmetry 2013, 24, 1193-1197. (link)

19. Champagne, P. A.; Pomarole, J.; Thérien, M.-E.; Benhassine, Y.; Beaulieu, S.; Legault, C. Y.; Paquin, J.-F.* “Enabling Nucleophilic Substitution Reaction of Activated Alkyl Fluorides Through Hydrogen-Bonding” Org. Lett. 2013, 15, 2210-2213. (link)

18. Guernon, H.; Legault, C. Y.* “N-Acyliminoimidazolium Ylides as Precursors to Anionic N-Heterocyclic Carbene Ligands: Control of Topology and Reactivity” Organometallics 2013, 32, 1988-1994. (link)


17. Guilbault, A.-A.; Basdevant, B.; Wanie, V.; Legault, C. Y.* “Catalytic α-Tosyloxylation of Ketones using Iodoaryloxazoline Catalysts: Insights on the Stereoinduction Process” J. Org. Chem. 2012, 77, 11283-11295. (link)

16. Ducharme, V.*; Égli, R.; Legault, C. Y.* “Energy-based Artificial Chemistry Simulator” In Artificial Life 13; Adami, C., Bryson, D. M., Ofria, C., Pennock, R. T., Eds.; MIT Press: Cambridge, 2012; 449-456. (link)

15. Beaumier, F.; Dupuis, M.; Spino, C.*; Legault, C. Y.* “Formal Intramolecular (4+1)-Cycloaddition of Dialkoxycarbenes : Control of the Stereoselectivity and a Mechanistic Portrait” J. Am. Chem. Soc. 2012, 134, 5938-5953. (Top 20 of most read articles, March 2012) (link)

14. Legault, C. Y.*; Prévost, J. “1-Fluoro-3,3-dimethyl-1,3-dihydro-1λ3-benzo[d][1,2]iodoxole” Acta Cryst. 2012, E68, o1238. (link)

13. Guilbault, A.-A.; Legault, C. Y.* “Drastic Enhancement of Activity in Iodane-Based α-Tosyloxylation of Ketones: Iodine(III) Does the Hypervalent Twist” ACS Catalysis 2012, 2, 219-222. (link)


12. Cheong, P. H.-Y.; Legault, C. Y.; Um, J. M.; Celebi-Olcum, N.; Houk, K. N.* "Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities and Selectivities" Chem. Rev. 2011, 111, 5042-5137. (link)


11. Garcia, Y.; Schoenebeck, F.; Legault, C. Y.; Merlic, C. A.; Houk, K. N. “Theoretical Bond Dissociation Energies of Halo-Heterocycles: Trends and Relationships to Regioselectivity in Palladium-Catalyzed Cross-Coupling Reactions.” J. Am. Chem. Soc. 2009, 131, 6632-6639. (link)

Travaux antérieurs/Previous work

10. Yu, Z.-X.; Cheong, P. H.-Y.; Liu, P.; Legault, C. Y.; Wender, P. A.; Houk, K. N. “Origins of Differences in Reactivities of Alkenes, Alkynes, and Allenes in [Rh(CO)2Cl]2-Catalyzed (5+2) Cycloaddition Reactions with Vinylcyclopropanes” J. Am. Chem. Soc. 2008, 130, 2378-2379. (link)

9. Legault, C. Y.; Charette, A. B.; Cozzi, P. G. “Iridium Catalyzed Enantioselective Hydrogenation of N-Iminopyridinium Ylides: Mechanistic Insights” Heterocycles 2008, 76, 1271-1283. (link)

8. Legault, C. Y.; Garcia, Y.; Merlic, C. A.; Houk, K. N. “Origin of Regioselectivity in Palladium-Catalyzed Cross-Coupling Reactions of Polyhalogenated Heterocycles” J. Am. Chem. Soc. 2007, 129, 12664-12665. (link)

7. Legault, C. Y.; Kendall, C.; Charette, A. B. “Structure and Reactivity of a New Anionic N-Heterocyclic Carbene Silver(I) Complex” Chem. Commun. 2005, 3826-3828. (link)

6. Legault, C. Y.; Charette, A. B. “Catalytic Asymmetric Hydrogenation of N-Iminopyridinium Ylides: Expedient Approach to Enantioenriched Substituted Piperidine Derivatives” J. Am. Chem. Soc. 2005, 127, 8966-8967. (link)

5. Charette, A. B.; Boezio, A. A.; Côté, A.; Moreau, E.; Pytkowicz, J.; Desrosiers, J.-N.; Legault, C. “Asymmetric Catalytic Addition of Diorganozinc Reagents to Imines: Scope and Application” Pure and Applied Chemistry 2005, 77, 1259-1267. (link)

4. Charette, A. B.; Legault, C.; Bélanger-Gariépy, F. “3,3-Pentamethylenediaziridine” Acta Cryst. 2004, E60, o1921-o1922. (Cover illustration of the issue and highlight in IUCr Newsletter 2004, 12, 7) (link)

3. Legault, C.; Charette, A. B. “Efficient Synthesis of O-(2,4-Dinitrophenyl)hydroxylamine. Application to the Synthesis of Substituted N-Benzoyliminopyridinium Ylides” J. Org. Chem. 2003, 69, 7119-7122. (link)

2. Legault, C.; Charette, A. B. “Complexation Promoted Additions to N-Benzoyliminopyridinium Ylides. A Novel and Highly Regioselective Approach to Polysubstituted Piperidines” J. Am. Chem. Soc. 2003, 125, 6360-6361. (link)

1. Faucher, A.-M.; Brochu, C.; Landry, S. R.; Duchesne, I.; Hantos, S.; Roy, A.; Myles, A.; Legault, C. “Chelation-Controlled Reduction of α- and β-Oxygenated Ketones with Lithium tri-n-Butylborohydride” Tetrahedron Lett. 1998, 39, 8425-8428. (link)

Contributions e-EROS/e-EROS Chapters

3. Schneider, Y.; Legault, C. Y. “Spiro[3H-diazirine-3,2′- tricyclo[]decane]” In Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS); Paquette, L. A.; Crich, D; Charette, A. B.; Fuchs, P. L.; Molander, G. A. (Eds.); Wiley: Chichester, 2015.

2. Meunier, A.; Legault, C. Y. “Manganese(III) acetate” In Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS); Paquette, L. A.; Crich, D; Charette, A. B.; Fuchs, P. L.; Molander, G. A. (Eds.); Wiley: Chichester, 2011.

1. Legault, C. Y. “N-(Benzoylimino)pyridinium betaine” In Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS); Paquette, L. A.; Crich, D; Charette, A. B.; Fuchs, P. L.; Molander, G. A. (Eds.); Wiley: Chichester, 2010.

35. Dagenais, R.; Jobin-Des Lauriers, A.; Legault, C. Y.* “Iodine(III)-Mediated Oxidative Hydrolysis of Haloalkenes: Investigation of the Effect of Iodine(III) Reagents” Synthesis 2017, 2928-2932 (Invited contribution). (link)

33. Basdevant, B.; Guilbault, A.-A.; Beaulieu, S.; Jobin-Des Lauriers, A.; Legault, C. Y.* "Iodine(III)-mediated synthesis of chiral α-substituted ketones: recent advances and mechanistic insights" Pure Appl. Chem. 2017, 89, 781-789. (Invited contribution). (link)

34. Cocaud, C.; Nicolas, C.; Poisson, T.; Pannecoucke, X.; Legault, C. Y.*; Martin, O.* “A Tunable Approach for the Stereoselective Synthesis of 1-C-Diethylphosphono(difluoromethyl) Iminosugars as Glycosyl Phosphate Mimics” J. Org. Chem. 2017, 82, 2753-2763. (link)


32. Jobin-Des Lauriers, A.; Legault, C. Y.* "Enol and Ynol Surrogates: Promising Substrates for Hypervalent Iodine Chemistry" Asian J. Org. Chem. 2016, 5, 1078-1099 (Invited contribution). (link)

31. Jobin-Des Lauriers, A.; Legault, C. Y.* "Iodine(III)-mediated Oxidative Hydrolysis of Haloalkenes : Access to α-Halo Ketones by a Release-and-Catch Mechanism" Org. Lett. 2016, 18, 108-111. (link)


37. Robidas, R.; Guérin, V.; Provençal, L.; Echeverria, M.; Legault, C. Y.* “Investigation of Iodonium Trifluoroborate Zwitterions as Bifunctional Arene ReagentsOrg. Lett. 2017, 19, 6420-6423. (link) (Highlighted in Synfacts 2018, 14, 145)

36. Labattut, A.; Tremblay, P.-L.; Moutounet, O.; Legault, C. Y.* “Experimental and Theoretical Quantification of the Lewis Acidity of Iodine(III) SpeciesJ. Org. Chem. 2017, 82, 11891-11896 (Invited contribution). (Top 20 of most read articles, August 2017) (link)


38. Nikolaev, A.; Legault, C. Y.; Zhang, M.; Orellana, A.* “The Acid-Free Cyclpropanol-Minisci Reaction Reveals the Catalytic Role of Silver-Pyridine Complexes” Org. Lett. 2018, 20, 796-799. (link)